Céline Dion's niece died in her arms at 16

Céline Dion lost her niece Karine to cystic fibrosis in 1993, as the latter took her last breath in the singer's arms at the age of 16. The disease has affected the star closely since 1982, leading her to actively support the Canadian Cystic Fibrosis Foundation, for which she is the national patron. The singer subsequently immortalized this family tragedy by dedicating the song Vole to her niece's memory on the album D'eux.