Mammalian respirasomes follow a precise organization

A respirasome is a supramolecular structure formed by the organization of respiratory complexes within the inner mitochondrial membrane. These protein associations allow for the optimization of electron transfer efficiency by channeling substrate flows between the various successive complexes. In mammals, the five components of oxidative phosphorylation I, II, III, IV and V are found in a characteristic ratio estimated at 1:1:3:7:4.